The QKI (pan) Antibody: PerCP from MyBioSource.com is a Mouse Monoclonal antibody to Qk, QK1, QK3, QKI, and Quaking. This antibody recognizes Human, Mouse, and Rat antigen. The QKI (pan) Antibody: PerCP has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Background Info: Detects a 36-38 kDa protein corresponding to the molecular weight of Pan-QKI
Scientific Background: QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients